Editorial Volume 8, Issue 12 pp 3153—3154

Figure 1. Proposed model of translational reprogramming of the SQSTM1/p62-Nrf2 axis contributing to CFZ resistance in LP-1/Cfz MM cells. Induction of Nrf2 target genes EIF4E3 (encoding eIF4E3) and RND3 (encoding Rnd3/RhoE) in LP-1/Cfz cells creates a positive feedback loop promoting eIF4E3-driven Nrf2 translation. FAM129A (encoding Niban) is a putative indirect Nrf2 target downregulated in LP-1/Cfz cells. Niban inhibits PERK-mediated phosphorylation of eIF2α. Additionally, Niban (negatively) and Rnd3 (positively) modulate the activity of 4E-BP1, an inhibitor of eIF4E1. NFE2L2 mRNA (encoding Nrf2) is indicated with a 5’-terminal 7-methyl guanosine cap (m⁷G) and a 3’-terminal poly(A) tail (AAAAAA). eIF4F, eukaryotic translation initiation complex containing eIF4E1, eIF4E3 and other components involved in cap-dependent translation initiation; red boxes, increased protein levels; blue box, decreased protein levels; P, phosphorylated form; arrows, positive regulation; bars, negative regulation; dotted lines, undetermined mechanisms. See ref [6]. for details.