Research Paper Volume 8, Issue 11 pp 3065—3090
Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation
Figure 2. Effects of LPS-induced acute inflammation on activation of mast cells located in mesentery close to mesenteric lymphatic vessels in adult (9 mo, n=4 for control and n=4 for LPS-treated groups) and aged (24 mo, n=4 for control and n=4 for LPS-treated groups) rats. (A) representative images of activated mast cells stained by Ruthenium Red in sham (ctrl) and LPS-treated mesenteric segments of both ages; (B) comparison of number of activated mast cells per region of interest (ROI) under various conditions; (C) similar data normalized to control conditions for that age group to demonstrate the fold change in number of mast cells activated by LPS. * indicates significant differences (p < 0.05, one-way ANOVA) between control and LPS-treated mesenteric segments within each age group. # indicates significant differences (p < 0.05, one-way ANOVA) between adult and aged mesenteric segments in control group or in LPS-treated group.