Research Paper Volume 8, Issue 11 pp 2927—2935

Figure 2. Determination of MDH1 levels in CSF of sCJD patients. MDH1 was quantified by ELISA in CSF of sCJD and control patients. (A) Patients with sCJD (n=82) exhibited a significantly increased level of MDH1 compared to controls (n=60). (B) ROC curve analysis was performed for the discrimination between sCJD patients and controls. (C-D) MDH1 analysis of different PRNP codon 129 genotypes and PrP^Sc types in sCJD patients revealed no significant differences within the sCJD cohort (only when compared to controls). AUC values, corresponding to the area under ROC curves, and 95% confidence intervals are reported. For comparison between groups we used One-way ANOVA or 1-way or Wilcoxon Mann Whitney and Tukey’s post hoc test. A p-value < 0.001 is considered as extremely significant (***), < 0.01 as very significant (**), < 0.05 as significant (*) and ≥ 0.05 as not significant (ns).