Research Paper Volume 8, Issue 11 pp 2915—2926
Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
Figure 4. PL synergistically and selectively kills SCs in combination with ABT-263. (A) Quantification of NC viability 72 h after the cells incubation with vehicle, 1.25 µM ABT-263, 10 µM PL, or the combination of ABT-263 and PL (n = 3). (B) Quantification of WI-38 IR-SC viability 72 h after incubation with vehicle, 1.25 µM ABT-263, 5 or 10 µM PL, or the combination of ABT-263 and PL (n = 3-5). (C) Quantification of WI-38 IR-SC viability 72 h after incubation with vehicle, 10 µM PL, 0.08-1.25 µM ABT-263, or the combination of ABT-263 and PL (n = 3-6). Data are represented as the mean ± SEM.