Research Paper Volume 8, Issue 11 pp 2814—2826
Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions
Figure 3. Caloric restriction decelerates the rate of decline of cerebral blood flow in aging mice. Old CR mice had significantly higher CBF in (A) Frontal cortex and (B) Hippocampus; however (C) P-gp activity did not show significance when compared with old AL mice. The age-dependent changes between AL and CR mice in (D) CBF within frontal cortex, and (E) hippocampus, and (F) Differnce in cortical P-gp activity, between AL and CR mice. Data are mean ± SEM. **p < 0.01; n.s.: non-significant; AL: ad libitum; CR: caloric restriction.