Research Paper Volume 8, Issue 11 pp 2814—2826
Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions
Figure 1. Caloric restriction enhances neurovascular functions in young mice. (A) CBF maps superimposed on structural brain images; the color code indicates the level of CBF in a linear scale. Quantitative CBF (ml/g/min) obtained from (B) Frontal Cortex and (C) Hippocampus. (D) Representative confocal images showing increased luminal accumulation of NBD-CSA fluorescence (green) in brain capillaries isolated from young CR mice; shown in arbitrary fluorescence units (scale 0-255). (E) Corresponding quantitative fluorescence data. Data are mean ± SEM. **p < 0.01; ***p < 0.001; n.s.: non-significant; AL: ad libitum; CR: caloric restriction.