Research Paper Volume 8, Issue 11 pp 2747—2753

Figure 4. Energy expenditure and activity of wild-type mice after treatment with PI3K inhibitors. (A) Left, energy expenditure (EE). Right, mean EE. Calorimetry of male WT mice, under ad libitum feeding, after a single oral dose of 15 mg/kg of the indicated PI3K inhibitors (n=7-8 per group, C57BL6 males, 20 weeks old). The line and asterisks indicate that CNIO-PI3Ki and BYL-719 are significantly different relative to vehicle at these time points. (B) Left, activity. Right, mean activity. Activity was measured in the same mice as in panel A. Values correspond to average ± s.e.m. Statistical significance was determined by the two-tailed Student’s t-test relative to vehicle controls: * p < 0.05, ** p <0.01.