Research Paper Volume 8, Issue 11 pp 2747—2753

Figure 1. Differential effects of PI3K inhibitors on obesity in ob/ob mice. (A) Body weight change relative to day 0 during daily dosing of the indicated PI3K inhibitors (n=10 per group, ob/ob males, 20 weeks old). The vehicle treated group is the same for the three graphs. (B) Relative body weight change at the end of the treatment (day 15 or 16) of the same experimental groups shown in panel A. Values correspond to average ± s.d. Statistical significance was determined by the two-tailed Student’s t-test relative to vehicle controls: *p < 0.05, ** p <0.01, *** p <0.001.