Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits

Stephen J. Bonasera; Jyothi Arikkath; Michael D. Boska; Tammy R. Chaudoin; Nicholas W. DeKorver; Evan H. Goulding; Traci A. Hoke; Vahid Mojtahedzedah; Crystal D. Reyelts; Balasrinivasa Sajja; A. Katrin Schenk; Laurence H. Tecott; Tiffany A. Volden

doi:doi:10.18632/aging.101040

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Research Paper Volume 8, Issue 9 pp 2153—2181

Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits

Figure 1. Strain-specific impairments in mouse mobility and energy balance occur with aging. Left: Decreased mean daily locomotion in aged C57BL/6 mice (filled rectangles), with preserved mean daily locomotion in aged BALB mice (open rectangles). Center: Body weight in aged C57BL/6 and BALB mice decreases between 12-13 months and 21-24 months. Right: Normalized food intake. For all figures, error bars are ± 1 standard error of the mean.