Research Paper Volume 8, Issue 9 pp 2204—2221

Figure 4. Survival prediction of ESCC patients by pTNM staging system and the combined TRIM24 protein expression with pTNM staging system. (A) OS (left panel) and DFS (right panel) outcomes of ESCC patients were predicted by pTNM staging system. (B) OS and DFS outcomes of ESCC patients were predicted by the combined TRIM24 protein expression and pTNM staging system, which show that the combined risk model significantly improves survival prediction of pTNM staging system (Stage I vs II, P =0.321; Group I vs II, P =0.007). (C) Receiver operating characteristic (ROC) analysis compares the survival prediction of ESCC patients by pTNM staging system, TRIM24 protein expression and the combination of both. The result shows that the area under the curve (AUC) of the combined model is the largest among the three predictors, which demonstrates that predictive accuracy of the combined risk model is better than those of pTNM staging system and TRIM24 protein alone.