Research Paper Volume 8, Issue 11 pp 2667—2688

Figure 3. Reductions in mature oligodendrocytes in 4- and 8-week-old BubR1 insufficient mice. (A) The density of oligodendrocyte lineage cells in the corpus callosum at 4 and 8 weeks of age. Left: Representative images of CC1 staining of 4 week-old WT and BubR1^H/H mice corpus callosum. Scale bars: 50 µm. Right: Quantification of CC1⁺ cell number in the corpus callosum. (B) The density of oligodendrocyte lineage cells in the white matter of spinal cord at 4 and 8 weeks of age. Left: Representative images of CC1 staining of 4 week-old WT and BubR1^H/H mice spinal cord. Scale bars: 50 µm. Right: Quantification of CC1⁺ cell density in the spinal cord. All values represent mean ± SEM (**P < 0.01, ***P < 0.001, student’s t-test). Number associated with bar graphs indicates number of animals examined.