Research Paper Volume 8, Issue 9 pp 1896—1922

Figure 4. Age-related changes of TDG mRNA levels in PBMC. Upper panels show scatter plots representing the linear correlation between TDG mRNA levels and age in PBMC calculated from (A1) non-transformed TDG data, (B1) log-transformed TDG data, (C1) batch-corrected TDG data, (D1) batch-corrected TDG data retaining age and gender differences. Parametric (Pearson r) and non-parametric (Spearman’s ρ) correlation coefficients and statistical significance are given above each graph. Lower panels show bar graphs reporting the expression levels of TDG gene in three different age classes calculated from (A2) non-transformed TDG data, (B2) log-transformed TDG data, (C2) batch-corrected TDG data, (D2) batch-corrected TDG data retaining age and gender differences. Boxplots show the median, the interquartile range (boxes) and the 5–95% data range (whisker caps). Comparisons between groups were performed by the Kruskal-Wallis test followed by post-hoc Bonferroni test. (y)= years.