Research Paper Volume 8, Issue 9 pp 1896—1922

Figure 2. Age-related changes of TET2 mRNA levels in PBMC. Upper panels show scatter plots representing the linear correlation between TET2 mRNA levels and age in PBMC calculated from (A1) non-transformed TET2 data, (B1) log-transformed TET2 data, (C1) batch-corrected TET2 data, (D1) batch-corrected TET2 data retaining age and gender differences. Parametric (Pearson r) and non-parametric (Spearman’s ρ) correlation coefficients and statistical significance are given above each graph. Lower panels show bar graphs reporting the expression levels of TET2 gene in three different age classes calculated from (A2) non-transformed TET2 data, (B2) log-transformed TET2 data, (C2) batch-corrected TET2 data, (D2) batch-corrected TET2 data retaining age and gender differences. Boxplots show the median, the interquartile range (boxes) and the 5–95% data range (whisker caps). Comparisons between groups were performed by the Kruskal-Wallis test followed by post-hoc Bonferroni test. (y)= years.