Research Paper Volume 8, Issue 2 pp 345—365
p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function
Figure 2. Correlations between p63 expression and other tumor associated factors. (A) The group with high International Prognostic Index (IPI) scores had a significantly higher mean level of p63 expression. (B-D) p63 expression was associated with significantly higher levels of p21, MDM2, and p16-INK4a in both germinal center B-cell like (GCB) and activated B-cell like (ABC) subtypes of DLBCL patients. (E-F) p63 expression was associated with significantly higher levels Ki-67 and Bcl-6 in ABC-DLBCL. (G) p63 expression was associated with significantly higher levels of IRF4/MUM-1 in both GCB and ABC subtypes of DLBCL patients. (H) p63+ ABC-DLBCL was associated with a trend toward higher c-Rel level. (I-J) The association of p63 expression with p21 and MDM2 is independent of p53 mutation status. (K-L) p53 mutation status did not impact the association with increased p16-INK4a, Bcl-6 and IRF4/MUM-1(figure not shown) levels.