Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes

María Eugenia Matzkin; Johanna Gabriela Miquet; Yimin Fang; Cristal Monique Hill; Daniel Turyn; Ricardo Saúl Calandra; Andrzej Bartke; Mónica Beatriz Frungieri

doi:doi:10.18632/aging.100875

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Research Paper Volume 8, Issue 1 pp 95—110

Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes

Figure 5. Longevity is inversely associated with testicular apoptosis. Quantification of apoptotic cells in testes of GH-Tg short-lived mice, GHRH-KO and Ames dwarf long-lived mice and their normal littermates was determined by TUNEL assay using a light microscope with a magnification of 400x and a gridded eyepiece. Results are expressed as TUNEL-positive cells/mm² and TUNEL-positive cells/tubule. Bar plot graphs represent the mean + SEM; n = 5-7. * p < 0.05, t-Student test.