Research Paper Volume 7, Issue 10 pp 793—810
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
Figure 2. Effects of gender on the average values of the biochemical parameters. (A) Stratified for gender. Population numbers are as follows: OCRs (Basal OCR, ATP turnover, Reserve capacity, Maximum capacity, Proton leak) and ECARs (Basal ECAR, Glycolytic reserve), men = 33, women = 35; ROS production, men = 18, women = 21; all dNTPs, men = 22, women = 33; DNA strand breaks, men = 31, women = 39; APE1 activity, men = 19, women = 17. Error bars represent ± standard deviation.
* Significant difference (P < .05) in the average level of the parameter between men and women.
(B) Stratified for both gender and control/AD. Population numbers in the order of control/men, control /women, AD/men, AD/women for each parameter were as follows: all OCR and ECARs, 13, 12, 20, 23; all dNTPs, 10, 17, 12, 16; ROS production, 8, 8, 10, 13; DNA strand breaks, 10, 16, 21, 23; APE1 activity, 8, 10, 11, 7. Error bars represent ± standard deviation. *Significant difference (P < .05) in the average level of the parameter between men and women.