Research Paper Volume 6, Issue 10 pp 820—834
Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism
Figure 6. Schematic illustration of how SIRT-1 may protect skeletal muscle from PARP-1-induced muscle fatigue. In young mice, SIRT-1 inhibits the exercise-induced PARP-1 activity by deacetylation-dependent mechanism and as a result increases skeletal muscle performance via enhanced mitochondrial biogenesis. In contrast, dysregulation of SIRT-1 in skeletal muscle from aged mice reduces skeletal muscle performance due to higher PARP-1 activity via GCN5 mediated acetylation. ROS, reactive oxygen species; NAD, nicotinamide adenine dinucleotide; Ac, acetylation; P, protein.