Research Paper Volume 6, Issue 4 pp 320—334
Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function
Figure 6. Proteomic changes suggest alterations in mitochondrial dynamics and mitophagy with age. (A) Heatmap of the protein expression changes from 5 to 12 month and 12 to 24 month in isolated synaptic mitochondria (log2 (12/5 months) and (24/12 months)). Gray box represents value not obtained in our proteomic experiment due to insufficient peptide confidence. Proteins highlighted in red were verified orthogonally. (B) Immunoblot validation of protein expression for selected proteins in (A).