Research Paper Volume 5, Issue 11 pp 825—834
Absence of ductal hyper-keratinization in Mouse age-related meibomian gland dysfunction (ARMGD)
Figure 4. Keratinization of the meibomian gland orifice. (A-C) A 5month and (D-F) 2year old mouse lid margin cross-sections. (D) Gland plugging and (D-F) a loss of CK1+ cells posterior to the orifice causes the mucocutaneous junction to shift anteriorly in the aged mouse eyelid. CK1 immunostaining shows no hyper-keratinization or obstruction in the atrophic meibomian glands.