Research Paper Volume 5, Issue 10 pp 759—769
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans
Figure 7. FUdR improves healthspan in wild-type animals at 25°C. A, B, Photomicrographs of autofluorescence from day 9 wild-type N2 animals aged at 25°C in the absence or presence of FUdR (100 μg/ml). C, Quantification of A, B. FUdR-treatment significantly decreases the levels of autofluorescent age-pigments compared to untreated control animals. (**=p<0.0001, Student's t-test). D, FUdR-treatment significantly extends mean lifespan of wild-type N2 animals at 25°C (42.5%±17.6%).