Research Paper Volume 5, Issue 10 pp 725—740

Figure 1. Identification of miRNAs in serum from young and old individuals. (A) Frequency of miRNA reads per individual using small RNA NGS from 11 young (~30 yr) and 11 old (~64 yr) individuals for miR-181a-1, miR-3607, miR-1248, miR-151a and miR-151b. Horizontal lines represent average number of reads. miR-181a, miR-1248 and miR-3607 were significantly downregulated in serum from old individuals using Poisson regression (miR-181a-1 P=0.03, miR-3607 P=0.01, miR-1248 P=4.9×10⁻⁹). (B) miRNAs identified that had only one read per individual.