Research Paper Volume 5, Issue 6 pp 427—444

Figure 3. Sucnr1−/− mice develop Bruch's membrane thickening. Transmission electron microscopy of BM (outlined in yellow) with annotated thickness bar (red). BM is systematically thicker in Sucnr1−/− mice at 8 weeks (A-C), and 20 weeks (D-F). High fat diet exacerbates the noted difference in BM thickness at 20 weeks (G-I). Data is compiled from 15 points of measure per retina in 4 distinct animals. **P<0,01. Scale bar: 1μm.