Research Paper Volume 4, Issue 11 pp 755—767

Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease


Figure 6. The effect of MIA-690, on the viability, free radical formation, enzyme and mediator expression of HCN-2 cells in vitro. Cells were treated with 10 μM amyloid-β1-42, and the combination treatments with 10 μM amyloid-β1-42 and the 3 doses (10 nM, 100 nM and 1 μM) of MIA-690. Abbreviations: ROS: reactive oxygen species, GPx: glutathione-peroxidase, BDNF: brain derived neurotrophic factor. * = p < 0.05 vs. control. Data are represented as mean +/− SEM.