Figure 6. Open field test and fear conditioning test in WT, mIGF-1 Tg and mIGF-1 Tg; SIRT1 CKO mice. (A, B) WT or mIGF-1 Tg mice were subjected to open field test. (C, D) WT, mIGF-1 Tg and mIGF-1 Tg; SIRT1 CKO mice underwent cue memory or conditional memory conditioning tests. Results are means ± SE of 3-8 animals for each genotype (*,**p versus WT mice).