Research Paper Volume 2, Issue 10 pp 678—690
Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans
Figure 5. Aberrant protein O-GlcNAc cycling differentially affects distinct stress response pathways in C. elegans. (A) Images and quantification of sod-3::GFP reporter expression upon inactivation of OGA-1 and the insulin pathway effector kinase AGE-1. (B) Images and quantification of hsp-16-2::GFP reporter expression upon inactivation of OGA-1 and AGE-1. Note that inactivation of AGE-1 by RNAi induces both SOD-3 and HSP-16 expression, while OGA-1 inactivation only induces SOD-3 expression. Asterisks denote statistically significant differences from vector RNAi controls (* p < 0.05 and ** p < 0.01).