Research Paper Volume 2, Issue 10 pp 650—658

Figure 2. Impaired telomerase activity impairs glucose tolerance and glucose-stimulated insulin secretion. (A) Serum glucose excursions following intraperitoneal injection of D-glucose; black line corresponds to control animals while grey line reflects Terc-/- G4 animals (also applies to panels B-D) (n=47 controls, n=25 Terc-/- G4). (B) Plasma insulin excursions following intraperitoneal injection of D-glucose (n=47 controls, n=25 Terc-/- G4). (C) Blood glucose excursion following intraperitoneal injection of insulin (n=24 controls, n=8 Terc-/- G4). (D) Exhalation of ¹³Carbon dioxide per constant time interval following intraperitoneal injection of ¹³C-labeled glucose (n=23 controls, n=8 Terc-/- G4). Typical quantitative fluorescence in situ hybridization (qFISH) appearances of a control (E) and Terc -/- G4 (F) islet, respectively. (G) depicts results of telomere length quantification by qFISH (n=23 control and n=10 Terc-/- G4 animals, 25 nuclei per mouse were evaluated; red bars are 20 μm of length).