Research Paper Volume 2, Issue 9 pp 567—581

Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans


Figure 2. A genetic interaction between Klotho and the EGL-17/EGL-15 (FGFR) signalling pathway can positively modulate lifespan. Adult worm lifespan analysis was performed at 20°C on RNAi plates as described in the text. Animals of indicated genotype were submitted to either klotho RNAi (solid symbol) or control L4440 vector RNAi (open symbol) throughout adulthood. See Table 1 for corresponding quantitative data and statistical analysis.