The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the <i>Klotho</i> mouse models of aging

C-C Hsieh; Makoto Kuro-o; Kevin P. Rosenblatt; Reynolds Brobey; John Papaconstantinou

doi:doi:10.18632/aging.100194

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Research Paper Volume 2, Issue 9 pp 597—611

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

Figure 5. Western blot analysis of pool level of ASK1 in the livers of Klotho^(-/-) and Klotho overexpressing mice. Western blot analyses of levels of ASK1 in the livers of (A) Klotho^(-/-)(129)and WT (129) mice and (B) the EFmKL46 Klotho overexpressing and WT mice. The bar graphs depict the mean +/- SE of samples from WT, Klotho^(-/-) and EFmKL 46 Klotho overexpressing mice.