The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the <i>Klotho</i> mouse models of aging

C-C Hsieh; Makoto Kuro-o; Kevin P. Rosenblatt; Reynolds Brobey; John Papaconstantinou

doi:doi:10.18632/aging.100194

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Research Paper Volume 2, Issue 9 pp 597—611

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

Figure 4. The effects of Klotho^(-/-) and Klotho overexpression on the nuclear and cytoplasmic localization of Nrf2. (A) Cytoplasmic and (B) nuclear levels of Nrf2 in the KL^(-/-) and EFmKL46 Klotho overexpressing mice.