Figure 5 — Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis

Research Paper|Volume 2, Issue 8|pp. 504–513

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis

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Figure 5.Metabolic pathways showing the interconversion of PIPs and putative roles of MIP and PI(3,5)P2. Through the specific action of different phosphatases, seven phosphoinosites molecules are generated. Note that a loss of MIP activity will lead to an increase in PI(3,5)P2 concentration and activity. Even small changes in content or activity of phosphatases and/or their substrates can lead to complex pathologies, including several muscle diseases.