Research Paper Volume 2, Issue 8 pp 504—513

Figure 4. Altered Ca⁺² homeostasis is present in muscle fibers from old Wt and MIPKO mice. Original traces representative of caffeine-induced Fura-2 Ca⁺² transients in mature Wt (black trace), old Wt (red trace), and mature MIPKO FDB muscle fibers (blue trace). Examples shown are representative of 6-12 muscle fibers from 3 mice, and data were normalized to the intracellular Ca⁺² concentrations in nM.