Figure 4. Altered Ca+2
homeostasis is present in muscle fibers from old Wt and MIPKO mice. Original traces
representative of caffeine-induced Fura-2 Ca+2 transients
in mature Wt (black trace), old Wt (red trace), and mature MIPKO FDB muscle
fibers (blue trace). Examples
shown are representative of 6-12 muscle fibers from 3 mice, and data were
normalized to the intracellular Ca+2 concentrations in nM.
