Research Paper Volume 2, Issue 7 pp 393—414

Figure 4. LCA and some other bile acids extend the CLS of WT strain under CR conditions. (A - D) Effect of various bile acids on survival (A) and on the mean and maximum life spans (B - D) of chronologically aging WT strain grown under CR conditions on 0.2% glucose. Data are presented as means ± SEM (n = 3-28; ***p < 0.001; **p < 0.01; *p < 0.05). (E) Structure and hydrophilic/hydrophobic properties of bile acids. The R1 (α), R3 (α) and R5 (α) hydroxyl groups at the positions 6, 7 and 12 in the six-member rings B and C of the steroid nucleus increase polarity of the hydrophilic (concave) side [α-face] of the nucleus by being located below the nucleus and axially to its plane. The R4 (β) hydroxyl group at the position 7 in the six-member ring B of the steroid nucleus confers polarity of the hydrophobic (convex) side [β-face] of the nucleus by being located above the nucleus and equatorially to its plane.