Figure 4.LCA and some other bile acids extend the CLS of WT strain under CR conditions.(A
- D) Effect of various bile acids on survival (A) and on the
mean and maximum life spans (B - D)
of chronologically aging WT strain grown under CR conditions on 0.2%
glucose. Data are presented as means ± SEM (n =
3-28; ***p < 0.001; **p < 0.01; *p < 0.05). (E)
Structure and hydrophilic/hydrophobic properties of bile acids. The R1
(α), R3 (α) and R5 (α) hydroxyl groups at the positions 6, 7
and 12 in the six-member rings B and C of the steroid nucleus
increase polarity of the hydrophilic (concave) side [α-face] of the
nucleus by being located below the nucleus and axially to its plane. The R4
(β) hydroxyl group at the position 7 in the six-member ring B of the
steroid nucleus confers polarity of the hydrophobic (convex) side
[β-face] of the nucleus by being located above the nucleus and
equatorially to its plane.
