Figure 2.Inflammation in obesity. Rapid growth of
adipose tissue leads to quick expansion of adipose tissue. When
angiogenesis or vessel dilation can not meet the demand for blood supply,
there will be an adipose tissue hypoxia (ATH) from lack of blood supply.
ATH will induce angiogenesis and trigger inflammation. Inflammation will
promote angiogenesis and vasodilation locally in the tissue for
extracellular remodeling. When inflammatory cytokines and fatty acids are
elevated in the circulation, they will promote energy expenditure
systemically. The inflammatory response may also induce hyperglycemia and
energy disposal through glucose excretion in urine. In this way,
inflammation acts through insulin resistance and hyperglycemia.
