Figure 6. Circadian
mutant mice do not demonstrate anxiety phenotype. (Upper panel,
left) Average horizontal velocity for all genotypes measured during 1h
on days 1 and 2. Average velocity does not significantly differ between wt
and Bmal1-/- animals; slight (~15%) but statistically significant
decrease in average velocity is detected for Clock/Clock and Cry1,2-/-
mice compared with wt and Bmal1-/-. (Upper panel, right)
Cumulative time spent in the center for all genotypes measured during 1 hr
on days 1 and 2. (Lower panel) Time spent in the center square of
the open field arena on days 1 and 2 by wt, Clock/Clock, Bmal1-/-,
and Cry1,2-/- mice. *P<0.05.
