Research Paper Volume 2, Issue 4 pp 200—223

Figure 4. Effect of AOX on mitochondrial bioenergetics and mtROS during aging. Oxygen consumption in state 3 (% of that in the young group) in 30 d old males (A) and 50 d old females. (B) AOX expression is not able to compensate the decrease in oxygen consumption associated with aging. mtROS generation (nmol H₂O₂/min.mg.prot) in 30 d old males (C) and 50 d old females (D). AOX expression diminishes mtROS production in both young and aged flies, and compensates for the age-associated increase. a, b and c denote statistically significant differences between groups (ANOVA, p < 0.05, n = 4-10 samples per group). Pyruvate+proline was used as substrate in all experiments. Plotted data are means ± SEM.