Figure 4.Effect of AOX on mitochondrial bioenergetics and mtROS during aging.Oxygen
consumption in state 3 (% of that in the young group) in 30 d old males (A)
and 50 d old females. (B) AOX expression is not able to compensate
the decrease in oxygen consumption associated with aging. mtROS generation
(nmol H2O2/min.mg.prot) in 30 d old males (C)
and 50 d old females (D). AOX expression diminishes mtROS production
in both young and aged flies, and compensates for the age-associated
increase. a, b and c denote statistically significant differences between
groups (ANOVA, p < 0.05, n = 4-10 samples per group).
Pyruvate+proline was used as substrate in all experiments. Plotted data are
means ± SEM.
