Mitochondrial ROS production correlates with, but does not directly regulate lifespan in drosophila
Figure 1.Mitochondrial ROS production versus lifespan in three wild type strains of Drosophila melanogaster. (A) Rate of mtROS production (assayed as H2O2, mean + SEM). a, b, c and d indicate statistically significant differences between groups (ANOVA, p < 0.05, n = 5-9 samples per group), m: male, f: female. (B) Survival curves. Combined data from two independent experiments using 100 flies per group per experiment. Mean, maximum lifespans (d) were: DAH males [39,49]; CS males (46, 53); OR males (63, 74); DAH females (79, 84); CS females (69, 81); OR females (86, 91).