A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

Øyvind Fensgård; Henok Kassahun; Izabela Bombik; Torbjørn Rognes; Jessica Margareta Lindvall; Hilde Nilsen

doi:doi:10.18632/aging.100127

← Back

Research Paper Volume 2, Issue 3 pp 133—159

A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

Figure 2. Network analysis revealed a close interconnection between the two enriched clusters in nth-1.. (A) Functional interactions among upregulated genes in the two clusters was analysed using FunCoup [54]. A network of 97 most probable links between 95 genes was returned, involving 31 of the 58 regulated genes (12 and 19 from cluster I and II, respectively). (B) Network analysis of the 45 downregulated genes resulted in a network of 79 most probable links between 71 genes from both clusters.