Figure 2.The Janus face of DNA methylation in aging.
Early-life adversity-induced hypomethylation centers on CpG residues mapping to
DNA-binding sites of the epigenetic reader and writer MeCP2 (red
lollipops). Once established, these methylation landmarks are maintained
and do not undergo further age-associated changes in methylation. In
contrast, age-associated hypomethylation maps across the entire AVP locus
without any obvious pattern or preference for potential DNA-binding sites
(black and white lollipops). In this regard, age-associated hypomethylation
appears to behave stochastically, while early-life adversity is targeted.
