Research Paper Volume 2, Issue 1 pp 43—62
Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
Figure 7. mIGF-1 protects the murine heart from PQ-induced oxidative stress. PQ was injected intraperitoneally at a concentration of 30 mg/kg, while control animals were injected with a saline solution. All mice were sacrificed 24 hours after injections. The figure shows representative Western blots of 4-hydroxy-2-nonenal (4-HNE) adduct products (left panel) and of malondialdehyde (MDA) adduct products (right panel) from wild type, mIGF-1 Tg, wild type plus PQ and mIGF-1 mice plus PQ. Three animals of a total of 10 are shown in both panels A and B.