Figure 1.Model of the leptin-dependent central control of bone mass, appetite and energy expenditure.
Leptin inhibits release of brainstem-derived serotonin, which favors bone
mass accrual and appetite through its action on hypothalamic neurons.
Serotonergic neurons are in blue; VMH, ventromedial hypothalamus; ARC,
arcuate; VMH is in purple and arcuate is in green.
