Figure 1.Regulation of CREB activation in the SIA neurons. In the presence of food, dopamine is
released from the dopaminergic neurons and activates the dopamine receptor
DOP-3 in the RIC neurons, possibly to decrease octopamine release. Dopamine
also inhibits octopamine-mediated signaling in the SIA neurons through the
dopamine receptors DOP-2 and DOP-3. In the absence of food, cessation of
dopamine signaling results in octopamine-mediated CREB activation through
the octopamine receptor SER-3. Exposure to water also induces CREB
activation in the SIA neurons independently of dopamine and octopamine.
