Figure 1.(A) TAp63
maintains adult stem cells (ASC) by transcriptionally activating p57
and repressing Ink4a/Arf, preventing premature aging. (B)
In the absence of TAp63, p57 mRNA levels are low, leading to
hyperproliferation of ASCs (shown in pink), and Ink4a/Arf levels are
high, resulting in a concomitant senescence of ASCs (shown in blue) and a
premature aging phenotype in TAp63 deficient mice. The interplay of
the p53 family, including TAp73, ΔNp73, and ΔNp63, remains to be
elucidated.
