Commentary Volume 1, Issue 9 pp 753—757

Figure 2. Working model of how repeated exposure to stress could change the pattern of mRNA expression in senescent cells. In response to stresses such as oxidative stress and heat shock senescence cells form a high number of stress granules (SGs). These SGs recruit several mRNAs leading to their translation inhibition. During its lifespan, a living organism is exposed repeatedly to a variety of stresses. This could trigger multiple cycles of SGs assembly/disassembly which in turn change the expression pattern of mRNAs encoding factors responsible of activation the senescence-associated secretory phenotypes (SASPs). Consequently, this could enhance the levels of these SASPs factors that will be secreted in the microenvironment promoting malignancy in neighboring cells.