Figure 9.TTP-mediated regulation of E6-AP in cervical cancer cells.The binding of
TTP to the ARE-containing E6-AP mRNA targets it for rapid degradation.
Black ovals represent putative 3' UTR AU-rich elements (AREs). The
subsequent loss of E6-AP expression allows for concurrent p53 protein
stabilization and inhibition of hTERT transcription leading to
cellular senescence.
