Research Paper Volume 1, Issue 9 pp 803—817
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase
Figure 9. TTP-mediated regulation of E6-AP in cervical cancer cells. The binding of TTP to the ARE-containing E6-AP mRNA targets it for rapid degradation. Black ovals represent putative 3' UTR AU-rich elements (AREs). The subsequent loss of E6-AP expression allows for concurrent p53 protein stabilization and inhibition of hTERT transcription leading to cellular senescence.