Figure 2.Chronic muscle use increases the expression of muscle and mitochondrial regulatory proteins in young and old animals. (A).Representative
Western blots and graphical summary (B) of the effects of chronic
contractile activity on the expression levels of proteins important for
mitochondrial biogenesis (PGC-1α, Tfam), apoptotic signaling (AIF,
HSP70), and aging (SIRT1), in muscles from young (closed bars) and old
(open bars) animals expressed as the fold increase in chronically
stimulated over control muscles (n = 6-11). (C) HSP70 protein
content is shown separately due to the difference in scale, compared to the
data in B. Data represent the mean ± SEM. * P < 0.05, stimulated
vs. control.
