Figure 7 — Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS)

Research Paper|Volume 1, Issue 9|pp. 784–802

Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS)

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Figure 7.The antioxidant, N-acetyl cysteine (NAC) attenuates the ROS-mediated activation of p38 MAPK by ROT in young and old wild-type and Ames dwarf fibroblasts. The bar graphs and Western blot analyses below each bar graph show a time course of the effects of ROT (20 μM and NAC + ROT treatment on the induction of phosphorylation of the p38 MAPK catalytic site residues, P-Thr¹⁸⁰/P-Tyr¹⁸², in young (4-6 mos) wild-type and Ames dwarf fibroblasts, and (B) in old (21-24 mos) wild type and Ames dwarf fibroblasts. n=4; * p<0.05 between wild-type and dwarf.