Figure 5. The effects of ROT (5. μM and 20 μM) on the induction of thioredoxin in fibroblasts derived from young (4-6 mos) and old (21-24 mos) wild-type and Ames dwarf mice. (A) Fibroblasts from young wild type and age matched dwarf mice. (B) Fibroblasts from old wild type and age matched dwarf mice.