Research Paper Volume 1, Issue 9 pp 784—802
Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS)
Figure 12. The effects of increasing concentrations of rotenone on the activation of p38 MAPK phosphorylation in young (4-6 mos), middle aged (10-12 mos) and old (21-24 mos). The bar graphs and western blot analyses below each bar graph show the pool levels of P-Thr180/P-Tyr182 p38 MAPK in (A) young (4-6 mos); (B) middle aged (10-12 mos) and (C) old (21-24 mos) wild-type and dwarf fibroblasts after treatment with increasing concentrations of ROT for 30 minutes. n=3, *p<0.05 between wild-type vs. dwarf.