Research Paper Volume 1, Issue 8 pp 723—732

Figure 3. Modeling of replicative senescence in hematopoiesis. Cell numbers of the different compartments are plotted over a time course of 140 years (A: LT-HSC; B: ST-HSC; C: MPC; D: CPC; E: precursors; F: mature cells). The plots A-F depict the dynamics of the cells. In addition the progression of the signal is demonstrated (G). Input cell numbers were chosen close to the local equilibrium. Our model demonstrates that, under the assumptions on model parameters, hematopoiesis can be maintained for more than 100 years with a restriction to 50 cell divisions. However, the number of mature cells declines over time and the feedback signal increases correspondingly. Therefore the percentage of self-renewal increases resulting in a higher number of stem cells and progenitor cells.