Figure 2.Replicative senescence in hematopoietic development.
In this model we
have addressed the question if hematopoiesis is compatible with a
restriction in cell divisions (e.g. 50 cell divisions). Upon each division
the daughter cells may either remain on the same maturation level or
proceed to the next step of differentiation. Proliferation rates increase
upon differentiation and the estimated times are indicated for each
maturation step. Mature cells are post-mitotic and die after 20 days.
